Metformin is most frequently  detected in the soil of Mezquital Valley, which can be the result of further degradation of corn sugar in a warm climate, indicating sugar degradation during transport/storage and the water treatment process. Degradation of metformin was found to be both biotic and abiotic and the two processes produced many short chain compounds and several metabolites that include guanylurea. Not just the wastewater, but also the frequent consumption of vegetables and beans cultivated in Mezquital Valley could also pose a health risk for populations.